@article{Silva_Araújo Silva_Medeiros_Medeiros_2020, title={EFFECT OF PNEUMOPERITONEUM IN MODEL OF ABDOMINAL SEPSIS}, volume={11}, url={https://periodicos.ufrn.br/jscr/article/view/20837}, DOI={10.20398/jscr.v11i1.20837}, abstractNote={<p><strong>ABSTRACT</strong></p> <p><strong>Purpose: </strong>This study aims to examine the effects of CO<sub>2</sub> pneumoperitoneum on the level of inflammation biomarkers in a model of abdominal sepsis in rats.<strong> Methods: </strong>Twelve Wistar rats were randomly assigned to two groups of 6 rats each. Under anesthesia, abdominal sepsis was induced by cecal ligation and puncture (CLP). Rats were observed for 24 hours. Group 1: sepsis; group 2: sepsis + pneumoperitoneum with CO<sub>2</sub> for 30 min. Six hours after pneumoperitoneum deflation, blood samples were collected by cardiac puncture to measure (TNF?), interleukin-1? (IL-1?), interleukin-6 (IL-6), C-reactive protein (PCR) and procalcitonin (PCT). Statistical analysis using Student t test (p<0.05).<strong> Results: </strong>All animals survived. The rats with sepsis + pneumoperitoneum had levels of TNF?, IL-1? and IL-6 (542.4 ± 21pg / mL; 312.1 ± 12 pg / mL and 115.4 ± 11 pg / mL (respectively ), significantly lower than in the sepsis group (p = 0.01). Serum cytokine levels in the sepsis group were TNF? = 733.2 ± 24pg / mL; IL-1? = 432.1 ± 15 pg / mL and IL-6 = 232.3 ± 16 pg / mL. Serum levels of PCT and CRP were significantly lower in the sepsis + pneumoperitoneum group than in the sepsis group. (p=0.01). <strong>Conclusion: </strong>In conclusion, pneumoperitoneum CO2 attenuates the biomarkers of the acute phase inflammatory response associated with perioperative sepsis by PLC.</p>}, number={1}, journal={JOURNAL OF SURGICAL AND CLINICAL RESEARCH}, author={Silva, Cybelle Dutra and Araújo Silva, Evelynne Mayara and Medeiros, Vítor Brasil and Medeiros, Aldo Cunha}, year={2020}, month={May}, pages={31–38} }