TY - JOUR AU - Holanda, Cecília Maria de Carvalho Xavier AU - Barbosa, Vanessa Santos de Arruda AU - Rodrigues, Yullyanna Moreira AU - Saraiva, Eider Maia AU - Demeda, Vanessa Fávero AU - Medeiros, Hilkéa Carla Sousa de AU - Açucena, Maria Kadja Meneses Torres AU - Sampaio, Tarciso Bruno Montenegro AU - Medeiros, Aldo da Cunha PY - 2014/02/03 Y2 - 2024/03/28 TI - Effect of Propolis Extract on Biodistribution of Sodium Pertechnetate (Na99mTcO4) JF - JOURNAL OF SURGICAL AND CLINICAL RESEARCH JA - J Surg Cl Res VL - 4 IS - 1 SE - ORIGINAL ARTICLE DO - 10.20398/jscr.v4i1.4488 UR - https://periodicos.ufrn.br/jscr/article/view/4488 SP - 1-8 AB - <p>Objective: <em>Propolis</em> is a bee product useful natural substance applied in medicine. We have investigated the effect of <em>propolis</em> extract on biodistribution of sodium pertechnetate (Na<sup>99m</sup>TcO<sub>4</sub>)and laboratorial parameters in rats. Methods: It was administered, by gavage, 1.0ml/day of <em>propolis</em> into 10 rats (treated group) during 10 days and 1.0 ml/day of saline solution into other 10 rats (control group), by the same via and period. On the 10<sup>th</sup> day, after 60min, all the animals received 0.1ml of Na<sup>99m</sup>TcO<sub>4 </sub>by ocular via. 50% of each group of rats was killed after 10min and other 50%, after 30min. Samples of brain, stomach, small bowel, liver, kidneys, thyroid and lungs were isolated and the %ATI/g of each organ was calculated. Tissue samples were taken from all the organs and stained by HE and PAS. Data were compared by Mann–Whitney and Student’s t-tests (p&lt;0.05). Results: There was a statistically significant increase in the %ATI/g, from control to treated group, respectively, in small bowel (0.15±0.01 to 0.32±0.09, after 10min and 0.32±0.03 to 0.42±0.02, after 30min) and blood (0.22±0.01 to 0.48±0.02, after10min and 0.38±0.02 to 0.51±0.04, after 30min).Conclusion: <em>Propolis</em> extract facilitated the uptake of Na<sup>99m</sup>TcO<sub>4 </sub>in some organs of rats and increased levels of some laboratorial parameters.</p><p><strong>Keywords</strong>: <em>Propolis</em>. Herbal Medicine. Sodium Pertechnetate Tc 99m. Radiopharmaceuticals.Rats</p> ER -