Use of simvastatin in the prevention of cyclophosphamide-induced ureteral mucositis


  • Beatriz Stephanie da Silva Maia UFRN, Brazil
  • Lívia Medeiros Soares Celani Federal University of Rio Grande do Norte
  • Marília Daniela Ferreira de Carvalho Moreira Federal University of Rio Grande do Norte
  • Irami Araújo-Filho Federal University of Rio Grande do Norte
  • Aldo Cunha Medeiros



Ureter. Mucositis. Cyclophosphamide. Simvastatin. Treatment. Rats


Purpose: This study was designed to investigate the pharmacological efficacy of simvastatin against ureteral mucositis cyclophosphamide-induced. Methods: Wistar rats weighing 287±14g were used. A single dose of cyclophosphamide (CYP) 200mg/kg IP + oral simvastatin (10mg/kg) were administered in the (CYP/SIMV)  group (n=6), In the group (CYP/SAL) (n=6), saline v.o. was administered. The animals were weighed daily. After 7 days of CYP administration, blood was collected by cardiac puncture under anesthesia. After euthanasia, uterers were collected for histopathology. Serum TNF-?, IL-1?, IL-6 were determined by ELISA.  Results: CYP-induced ureteral mucositis in rats resulted in a significant increased level of serum cytokines (TNF-?, IL-1b, IL-6). Simvastatin treated rats showed significant decreased level of inflammatory cytokines. In body weight records, CYP-treated rats showed visible significant body mass loss compared to untreated rats (p<0.05). Edema and inflammatory cells in ureter tissues were reduced after simvastatin treatment, as demonstrated in histological H-E staining. Conclusion: In conclusion, our current findings provided scientific evidence that oral simvastatin positively influenced benefits against cyclophosphamide-induced ureter mucositis, which possibly has occurred by inactivating cytokines.


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Author Biography

Aldo Cunha Medeiros

Department of Surgery

Nucleous of Exprimental Surgery, Chair



How to Cite

MAIA, B. S. da S.; CELANI, L. M. S.; MOREIRA, M. D. F. de C.; ARAÚJO-FILHO, I.; MEDEIROS, A. C. Use of simvastatin in the prevention of cyclophosphamide-induced ureteral mucositis. JOURNAL OF SURGICAL AND CLINICAL RESEARCH, [S. l.], v. 8, n. 2, p. 130–139, 2018. DOI: 10.20398/jscr.v8i2.14302. Disponível em: Acesso em: 24 sep. 2022.