Effect of Propolis Extract on Biodistribution of Sodium Pertechnetate (Na99mTcO4)


  • Cecília Maria de Carvalho Xavier Holanda Federal University of Rio Grande do Norte
  • Vanessa Santos de Arruda Barbosa UFCG
  • Yullyanna Moreira Rodrigues UFRN
  • Eider Maia Saraiva UFRN
  • Vanessa Fávero Demeda UFRN
  • Hilkéa Carla Sousa de Medeiros UFRN
  • Maria Kadja Meneses Torres Açucena UFRN
  • Tarciso Bruno Montenegro Sampaio UNIVERSIDADE POTIGUAR -UnP
  • Aldo da Cunha Medeiros Federal University of Rio Grande do Norte






Objective: Propolis is a bee product useful natural substance applied in medicine. We have investigated the effect of propolis extract on biodistribution of sodium pertechnetate (Na99mTcO4)and laboratorial parameters in rats. Methods: It was administered, by gavage, 1.0ml/day of propolis into 10 rats (treated group) during 10 days and 1.0 ml/day of saline solution into other 10 rats (control group), by the same via and period. On the 10th day, after 60min, all the animals received 0.1ml of Na99mTcO4 by ocular via. 50% of each group of rats was killed after 10min and other 50%, after 30min. Samples of brain, stomach, small bowel, liver, kidneys, thyroid and lungs were isolated and the %ATI/g of each organ was calculated. Tissue samples were taken from all the organs and stained by HE and PAS. Data were compared by Mann–Whitney and Student’s t-tests (p<0.05). Results: There was a statistically significant increase in the %ATI/g, from control to treated group, respectively, in small bowel (0.15±0.01 to 0.32±0.09, after 10min and 0.32±0.03 to 0.42±0.02, after 30min) and blood (0.22±0.01 to 0.48±0.02, after10min and 0.38±0.02 to 0.51±0.04, after 30min).Conclusion: Propolis extract facilitated the uptake of Na99mTcO4 in some organs of rats and increased levels of some laboratorial parameters.

Keywords: Propolis. Herbal Medicine. Sodium Pertechnetate Tc 99m. Radiopharmaceuticals.Rats


Download data is not yet available.

Author Biographies

Cecília Maria de Carvalho Xavier Holanda, Federal University of Rio Grande do Norte

Department of Microbiology and Parasitology

Experimental Radiobiology and Antiparasitic Assays Laboratory

Aldo da Cunha Medeiros, Federal University of Rio Grande do Norte

Department of Surgery

Nucleus of Experimental Surgery



How to Cite

HOLANDA, C. M. de C. X.; BARBOSA, V. S. de A.; RODRIGUES, Y. M.; SARAIVA, E. M.; DEMEDA, V. F.; MEDEIROS, H. C. S. de; AÇUCENA, M. K. M. T.; SAMPAIO, T. B. M.; MEDEIROS, A. da C. Effect of Propolis Extract on Biodistribution of Sodium Pertechnetate (Na99mTcO4). JOURNAL OF SURGICAL AND CLINICAL RESEARCH, [S. l.], v. 4, n. 1, p. 1–8, 2014. DOI: 10.20398/jscr.v4i1.4488. Disponível em: https://periodicos.ufrn.br/jscr/article/view/4488. Acesso em: 24 sep. 2022.