Volume replacement with coconut water in rats with hemorrhagic shock

Authors

  • Domitila Costa de Farias Federal University of Rio Grande do Norte
  • Juliana Câmara Mariz Federal University of Rio Grande do Norte
  • Paula de Medeiros Nacácio Silva Federal University of Rio Grande do Norte
  • Vanessa de Fátima Lima Paiva Medeiros Federal University of Rio Grande do Norte
  • Robson Macedo-Filho Federal University of Rio Grande do Norte
  • Marília Daniela Ferreira de Carvalho Federal University of Rio Grande do Norte
  • Irami Araújo-Filho Federal University of Rio Grande do Norte
  • Amália Cínthia Meneses Rêgo University Potiguar
  • Italo Medeiros de Azevedo Federal University of Rio Grande do Norte http://orcid.org/0000-0002-1507-7401
  • Aldo da Cunha Medeiros Federal University of Rio Grande do Norte

DOI:

https://doi.org/10.20398/jscr.v4i2.5490

Keywords:

Hemorrhagic shock, Coconut water, Whole blood, Resuscitation

Abstract

Purpose: Hemorrhagic shock+trauma is the third leading cause of death worldwide, supported by its frequency, severity and ability to induce systemic inflammatory responses and damage a number of organs. Currently, there is not an ideal fluid for volume replacement. There is relevant knowledge regarding the nutritional composition of coconut water (CW), but studies regarding its use for resuscitation in cases of hemorrhagic shock are lacking. The aim of this study is to evaluate the efficacy of modified coconut water (3% sodium) for resuscitation in hemorrhagic shock in an experimental model in rats. Methods: Wistar rats weighing 250-300g were used. In group 1 (n = 6) shock + coconut water (CW); group 2 (n=6) shock + fresh whole blood (FWB); group 3 (n = 6) shock+saline 0.9% (S). At the end of the experiment, levels of TNF, IL-1, IL-2, C-reactive Protein, AST, ALT, urea, creatinine were measured. Results: All animals survived the procedures and tests by the end of the experiment. There was a significant reduction in liver function tests (ALT and AST), urea and creatinine in animals treated with CW, compared with those treated with FWB and S (p <0, 05). However, no significant differences were observed when the parameters were compared between FWB and saline (p> 0.05) groups. The TNF-a, IL-1b and IL-2 expression were significantly lower in rats treated with CW than in rats treated with FWB and S (p <0.05). In animals treated with CW the mean level of C-reactive protein was lower than in saline rats (P <0.05). Conclusion: Our results demonstrate that, in rats with hemorrhagic shock, i.v. coconut water administration preserved renal and hepatic function, and was superior to fresh whole blood and saline with regard to proinflammatory cytokine expression.

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Published

11-07-2014

How to Cite

FARIAS, D. C. de; MARIZ, J. C.; SILVA, P. de M. N.; MEDEIROS, V. de F. L. P.; MACEDO-FILHO, R.; CARVALHO, M. D. F. de; ARAÚJO-FILHO, I.; RÊGO, A. C. M.; AZEVEDO, I. M. de; MEDEIROS, A. da C. Volume replacement with coconut water in rats with hemorrhagic shock. JOURNAL OF SURGICAL AND CLINICAL RESEARCH, [S. l.], v. 4, n. 2, p. 35–44, 2014. DOI: 10.20398/jscr.v4i2.5490. Disponível em: https://periodicos.ufrn.br/jscr/article/view/5490. Acesso em: 24 sep. 2022.

Issue

Section

ORIGINAL ARTICLE