Toxicology of skin of Rana catesbeiana as a biological dressing in skin wounds of rats

Authors

  • João Pedro Santiago Paiva Marques Federal University of Rio Grande do Norte (UFRN)
  • Italo Medeiros Azevedo Federal University of Rio Grande do Norte (UFRN) https://orcid.org/0000-0002-1507-7401
  • Aldo Cunha Medeiros Federal University of Rio Grande do Norte (UFRN)

DOI:

https://doi.org/10.20398/jscr.v9i1.15732

Abstract

Purpose: The aim of this study was to evaluated the toxicity in rats’ kidney and liver by using Rana catesbeiana’s skin as biological dressing in skin wounds. Methods: Twenty Wistar rats were used; in all rats a back dorsum skin segment with 4 cm² was removed under anesthesia and aseptic technique. In group A (n=10) the wounds were treated with frog’s skin as a biological dressing. In group B (n=10) the wounds were treated with 1 mL of 0,9% saline solution. After 15 days, blood was collected for dosing serum AST, ALT, urea and creatinine. Results: Biochemical dosages evaluated liver and renal function tests. The values of AST, ALT, urea and creatinine showed no significant difference when the test and control groups were compared (p>0.05). Conclusion: The use of Rana catesbeiana’s skin as a biological dressing of rats wounds did not show toxic effects for liver and kidney functions.

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Published

11-10-2018

How to Cite

MARQUES, J. P. S. P.; AZEVEDO, I. M.; MEDEIROS, A. C. Toxicology of skin of Rana catesbeiana as a biological dressing in skin wounds of rats. JOURNAL OF SURGICAL AND CLINICAL RESEARCH, [S. l.], v. 9, n. 1, p. 24–32, 2018. DOI: 10.20398/jscr.v9i1.15732. Disponível em: https://periodicos.ufrn.br/jscr/article/view/15732. Acesso em: 6 oct. 2022.

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Section

ORIGINAL ARTICLE