Toxicology of skin of Rana catesbeiana as a biological dressing in skin wounds of rats

Resumo

Purpose: The aim of this study was to evaluated the toxicity in rats’ kidney and liver by using Rana catesbeiana’s skin as biological dressing in skin wounds. Methods: Twenty Wistar rats were used; in all rats a back dorsum skin segment with 4 cm² was removed under anesthesia and aseptic technique. In group A (n=10) the wounds were treated with frog’s skin as a biological dressing. In group B (n=10) the wounds were treated with 1 mL of 0,9% saline solution. After 15 days, blood was collected for dosing serum AST, ALT, urea and creatinine. Results: Biochemical dosages evaluated liver and renal function tests. The values of AST, ALT, urea and creatinine showed no significant difference when the test and control groups were compared (p>0.05). Conclusion: The use of Rana catesbeiana’s skin as a biological dressing of rats wounds did not show toxic effects for liver and kidney functions.