Effect of simvastatin on coagulation in rats with abdominal sepsis


  • Aldo Cunha Medeiros UFRN, Brazil
  • Irami Araújo-Filho UFRN, Brazil
  • Camila Carlos Tavares UFRN, Brazil
  • Nathalia Louise R Alves Mota UFRN, Brazil
  • Amália Cinthia Meneses Rêgo
  • Ítalo Medeiros de Azevedo
  • Vanessa de Fátima Lima Paiva Medeiros




Coagulation, Sepsis, Peritonitis, Simvastatin


Objective: This study aimed to evaluate the Simvastatin pleiotropic effects in coagulation on rats with abdominal sepis. Methods: Twelve Wistar rats (three months, 273-297g) were randomly assigned to abdominal septic group (n=6), induced by cecal ligation and pucture (CLP) and septic group with a previous drug treatment (n=6). The Simvastatin/CLP group was treated with oral simvastatin (10 mg/Kg), eighteen and two hours before the CLP procedure or normal saline solution 0.9%. Peripheral blood laboratory determinations: Platelets, ativated troboplastin parcial time, activated coagulation time, protrombin time, trombin time, fibrinogen dosage, factor VII and factor VIII. Statistical analysis was done by ANOVA and Tukey test, with p<0.05. Results: It wasn’t found any significant statistic differences between the groups. Conclusion: Simvastatin did not change the coagulation in rats with abdominal sepsis, according to this experimental model.


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How to Cite

MEDEIROS, A. C.; ARAÚJO-FILHO, I.; TAVARES, C. C.; MOTA, N. L. R. A.; RÊGO, A. C. M.; AZEVEDO, Ítalo M. de; MEDEIROS, V. de F. L. P. Effect of simvastatin on coagulation in rats with abdominal sepsis. JOURNAL OF SURGICAL AND CLINICAL RESEARCH, [S. l.], v. 3, n. 2, p. 68–74, 2013. DOI: 10.20398/jscr.v3i2.3569. Disponível em: https://periodicos.ufrn.br/jscr/article/view/3569. Acesso em: 2 oct. 2022.