Effect of simvastatin on coagulation in rats with abdominal sepsis

Resumo

Objective: This study aimed to evaluate the Simvastatin pleiotropic effects in coagulation on rats with abdominal sepis. Methods: Twelve Wistar rats (three months, 273-297g) were randomly assigned to abdominal septic group (n=6), induced by cecal ligation and pucture (CLP) and septic group with a previous drug treatment (n=6). The Simvastatin/CLP group was treated with oral simvastatin (10 mg/Kg), eighteen and two hours before the CLP procedure or normal saline solution 0.9%. Peripheral blood laboratory determinations: Platelets, ativated troboplastin parcial time, activated coagulation time, protrombin time, trombin time, fibrinogen dosage, factor VII and factor VIII. Statistical analysis was done by ANOVA and Tukey test, with p<0.05. Results: It wasn’t found any significant statistic differences between the groups. Conclusion: Simvastatin did not change the coagulation in rats with abdominal sepsis, according to this experimental model.