Impact of the autophagic process on antitumor treatment in pregnant women
Keywords:
Pregnancy; Cancer; Autophagic; Treatment.Abstract
The woman's body is undergoing major changes during pregnancy both physiologically and psychologically. The present work has as general objective to carry out a systematic review on the impact of the autophagic process in the antitumor treatment in pregnant women and as specific objectives: to analyze the regulation of autophagy in post-gestational breast cancer; describe the monitoring of gestational prenatal care. Autophagy is classically described as being induced by deprivation of nutrients and oxygen. However, other pro-autophagic signs are well characterized: the presence of damaged organelles or proteins and long-lived proteins; the presence of extracellular toxins; and cytotoxic compounds. The present study, however, points out that, although cell death is greater in cells with impaired autophagic flow, they have “side effects” in pregnancy, which can cause cell polarization to the mesenchymal profile of tumor stem cells, involved with the greater aggressiveness of the tumor.
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References
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