Phytochemical properties, therapeutic use and toxicity of Mentha piperita
Keywords:
Mentha piperita; Herbal plant; Phytochemical compounds; Toxicity.Abstract
Mentha piperita is a medicinal plant species originating from Europe and the Middle East, being widely cultivated in several regions due to its economic importance. The objective of this research was to demonstrate, through scientific productions, the therapeutic use, pharmacological, phytochemical and toxicity properties of Mentha piperita; For this, an integrative literature review was developed, whose searches were performed in the VHL (Virtual Health Library), SciELO (Scientific Electronic Library Online) and PubMed databases, by combining the following descriptors: Mentha piperita; Therapeutic use; Pharmacological; Phytochemical compounds; and Toxicity. The 19 selected scientific productions evidenced the therapeutic use of M. piperita in traditional medicine, against respiratory, digestive, muscular symptoms, nerve pain and itching. In modern medicine, it has a beneficial effect on liver fibrosis, kidney damage, nausea, vomiting, lack of appetite, cognitive activities and mental fatigue. Of the various phytochemical constituents, menthol and menthone were the most reported. M. piperita is an antioxidant against hepatotoxicity, renotoxicity, oxidative stress, it is regenerative and cell repair. In addition, it has pro-survival action on nematodes, pro-oxidant action and toxicity effect on crustacean larvae. As pharmacological properties, stood out antimicrobial, antifungal, amoebic, larvicide and anti-inflammatory activities. From this perspective, this herbaceous has promising application in several scientific and medical segments.
Downloads
References
AFZAL, S.; AHMAD, H. I.; JABBAR. A.; TOLBA, M. M. et al. Use of Medicinal Plants for Respiratory Diseases in Bahawalpur, Pakistan. BioMed Research International, v. 2021, p. 1-10, 2021.
ALEXA, E.; DANCIU, C.; RADULOV, I.; OBISTIOIU, D. et al. Phytochemical screening and biological activity of Mentha× piperita L. and Lavandula angustifolia mill. extracts. Analytical Cellular Pathology, v. 2018, p. 1-7, 2018.
ANCHISI, C.; MELONI, M. C.; MACCIONI, A. M. Chitosan beads loaded with essential oils in cosmetic formulations. Journal of cosmetic science, v. 57, n. 3, p. 205-214, 2006.
ASHRAFI, B.; RASHIDIPOUR, M.; MARZBAN, A.; SOROUSH, S. et al. Mentha piperita essential oils loaded in a chitosan nanogel with inhibitory effect on biofilm
formation against S. mutans on the dental surface. Carbohydrate polymers, v. 212, p. 142-149, 2019.
BELLASSOUED, K.; HSOUNA, A. B.; ATHMOUNI, K.; VAN PELT, J. et al. Protective effects of Mentha piperita L. leaf essential oil against CCl4 induced hepatic oxidative damage and renal failure in rats. Lipids in health and disease, v. 17, n. 1, p. 1- 14, 2018.
BITTNER FIALOVÁ, S.; KURIN, E.; TRAJ?ÍKOVÁ, E.; JÁNOŠOVÁ, L., et al. Mentha rhizomes as an alternative source of natural antioxidants. Molecules, v. 25, n. 1, p. 200, 2020.
BURT, S. Essential oils: their antibacterial properties and potential applications in foods—a review. International journal of food microbiology, v. 94, n. 3, p. 223-253, 2004.
CAPPELLARI, L. D. R.; SANTORO, M. V.; SCHMIDT, A.; GERSHENZON, J. et al. Improving phenolic total content and monoterpene in Mentha piperita by using salicylic acid or methyl jasmonate combined with Rhizobacteria inoculation. International Journal of Molecular Sciences, v. 21, n. 1, p. 50, 2020.
?AVAR ZELJKOVI?, S.; ŠIŠKOVÁ, J.; KOMZÁKOVÁ, K.; DE DIEGO, N. et al. Phenolic compounds and biological activity of selected Mentha species. Plants, v. 10, n. 3, p. 550, 2021.
DA SILVA RAMOS, R.; RODRIGUES, A. B. L.; FARIAS, A. L. F.; SIMÕES, R. C. et al. Chemical composition and in vitro antioxidant, cytotoxic, antimicrobial, and larvicidal activities of the essential oil of Mentha piperita L. (Lamiaceae). The Scientific World Journal, v. 2017, p. 1-8, 2017.
DE SOUSA, A. A. S.; SOARES, P. M. G.; DE ALMEIDA, A. N. S.; MAIA, A. R. et al. Antispasmodic effect of Mentha piperita essential oil on tracheal smooth muscle of rats. Journal of ethnopharmacology, v. 130, n. 2, p. 433-436, 2010.
DO ESPIRITO SANTO, É.; DE SOUZA, R. B.; LENHARDT, E. H. et al. Screening e avaliação antifúngica do hidrolato e do óleo essencial de Mentha piperita. Visão Acadêmica, v. 21, n. 3, 2020.
DOUROS, A.; BRONDER, E.; ANDERSOHN, F.; KLIMPEL, A. et al. Herb-induced liver injury in the Berlin case-control surveillance study. International journal of molecular sciences, v. 17, n. 1, p. 114, 2016.
ERGÜDEN, C.; ÖZKOÇ, S.; ÖZTÜRK, B.; DELIBA?, B. et al. Investigation of the in vitro effects of Melissa officinalis L., Mentha x piperita L. and Ocimum basilicum L. (Lamiaceae) essential oils on the cysts and trophozoites of Acanthamoeba castellani. Mikrobiyoloji bulteni, v. 50, n. 4, p. 569-579, 2016.
GHAVAMI, M. B.; POORRASTGOO, F.; TAGHILOO, B.; MOHAMMADI, J. et al. Repellency effect of essential oils of some native plants and synthetic repellents against human flea, Pulex irritans (Siphonaptera: Pulicidae). Journal of arthropod-borne diseases, v. 11, n. 1, p. 105-115, 2017.
JAFARIMANESH, H.; AKBARI, M.; HOSEINIAN, R.; ZAREI, M. et al. The effect of peppermint (Mentha piperita) extract on the severity of nausea, vomiting and anorexia in patients with breast cancer undergoing chemotherapy: a randomized controlled trial. Integrative Cancer Therapies, v. 19, p. 1534735420967084, 2020.
JAYAN, L.; PRIYADHARSINI, N.; RAMYA, R.; RAJKUMAR, K. Evaluation of antifungal activity of mint, pomegranate and coriander on fluconazole-resistant Candida glabrata. Journal of oral and maxillofacial pathology: JOMFP, v. 24, n. 3, p. 517-522, 2020.
KENNEDY, D.; OKELLO, E.; CHAZOT, P.; HOWES, M. J. et al. Volatile terpenes and brain function: investigation of the cognitive and mood effects of Mentha× piperita L. essential oil with in vitro properties relevant to central nervous system function. Nutrients, v. 10, n. 8, p. 1029, 2018.
KHERODA DEVI, M.; THANGJAM, I.; SINGH, W. Phytochemical screening of selected twelve medicinal plants commonly used as spices and condiments in manipur, north-east India. International Journal of - Science and Research, v. 8, p. 2945-2947, 2019.
LI, S.; WANG, A.; LIU, L.; TIAN, G. et al. Extraction of polysaccharides under vacuum condition from Lentinus edodes stipe and their antioxidant activities in vitro. Food Science and Biotechnology, v. 28, n. 3, p. 759-767, 2019.
MAHENDRAN, G.; RAHMAN, L. Ethnomedicinal, phytochemical and pharmacological updates on Peppermint (Mentha × piperita L.) - A review. Phytotherapy Research, v. 34, n. 9, p. 2088-2139, 2020.
MARWA, C.; FIKRI-BENBRAHIM, K.; OU-YAHIA, D.; FARAH, A. African peppermint (Mentha piperita) from Morocco: Chemical composition and antimicrobial properties of essential oil. Journal of advanced pharmaceutical technology & research, v. 8, n. 3, p. 86-90, 2017.
MASIERO, M. A.; VIANA, C. M. S. S.; DE LIMA, D. M.; DA SILVA, E. C. et al. Substratos no enraizamento de estacas de Mentha piperita L. Revista Brasileira de Agropecuária Sustentável, v. 10, n. 1, p. 234-240, 2020.
MIMICA-DUKIC, N.; BOZIN, B. Mentha L. species (Lamiaceae) as promising sources of bioactive secondary metabolites. Current Pharmaceutical Design, v. 14, n. 29, p. 3141-3150, 2008.
MOGOSAN, C.; VOSTINARU, O.; OPREAN, R.; HEGHES, C. et al. A comparative analysis of the chemical composition, anti-inflammatory, and antinociceptive effects of the essential oils from three species of Mentha cultivated in Romania. Molecules, v. 22, n. 2-11, p. 263, 2017.
OGALY, H. A.; ELTABLAWY, N. A.; ABD-ELSALAM, R. M. Antifibrogenic influence of Mentha piperita L. essential oil against CCl4-induced liver fibrosis in rats. Oxidative medicine and cellular longevity, v. 2018, p. 1-15, 2018.
PEREIRA, C.; BARROS, L.; FERREIRA, I. C. F. R. Plantas aromáticas usadas como condimentos: prevalência de ácidos gordos polinsaturados. Revista de Ciências Agrárias, v. 40, n. spe, p. 155-159, 2017.
RADAELLI, M.; SILVA, B. P. D.; WEIDLICH, L.; HOEHNE, L. et al. Antimicrobial activities of six essential oils commonly used as condiments in Brazil against Clostridium perfringens. brazilian journal of microbiology, v. 47, p. 424-430, 2016.
RAJKOWSKA, K.; OTLEWSKA, A.; KUNICKA-STYCZY?SKA, A.; KRAJEWSKA, A. Candida albicans impairments induced by peppermint and clove oils at sub-inhibitory concentrations. International journal of molecular sciences, v. 18, n. 1307, p. 1-11, 2017.
SINGH, S. S.; WONG, J. H.; NG, T. B.; SINGH, W. S. et al. Biomedical Applications of Lectins from Traditional Chinese Medicine. Current Protein and Peptide Science, v. 20
SOUZA, G. S.; OLIVEIRA, U. C.; SILVA, J. S.; LIMA, J. C. Crescimento, produção de biomassa e aspectos fisiológicos de plantas de Mentha piperita L. cultivadas sob diferentes doses de fósforo e malhas coloridas. Global Science and Technology, v. 6, n. 3, p. 35-44, 2013.
SOUZA, M. T.; SILVA, M. D.; CARVALHO, R. Revisão integrativa: o que é e como fazer. Einstein (São Paulo), v. 8, p. 102-106, 2010.
SULAIMAN; SHAH, S. M.; SADAF.; AMIM, M.; et al. Ethnoecological, elemental, and phytochemical evaluation of five plant species of lamiaceae in peshawar, Pakistan. Scientifica, v. 2020, p. 1-8, 2020.
UNSAL, V.; CICEK, M.; SABANCILAR, ?. Toxicity of carbon tetrachloride, free radicals and role of antioxidants. Reviews on Environmental Health, v. 36, n. 2, p. 279– 295, 2021.
VIEIRA, L.S. Fitoterapia da Amazônia: Manual de plantas medicinais (a farmácia de Deus). 2.ed. São Paulo: Agronômica Ceres, 1992. 347p.
WU, Z.; TAN, B.; LIU, Y.; DUNN, J. et al. Chemical composition and antioxidant properties of essential oils from peppermint, native spearmint and scotch spearmint. Molecules, v. 24, n. 15, p. 2825, 2019.
, n. 3, p. 220-230, 2019.
Português (Brasil)
English
Español (España)