Propiedades fitoquímicas, uso terapéutico y toxicidad de Mentha piperita
Palabras clave:
Mentha piperita; Planta de hierbas; Compuestos fitoquímicos; Toxicidade.Resumen
Mentha piperita es una especie de planta medicinal originaria de Europa y Medio Oriente, siendo ampliamente cultivada en varias regiones debido a su importancia económica. El objetivo de esta investigación fue demostrar, a través de producciones científicas, el uso terapéutico, las propiedades farmacológicas y fitoquímicas y la toxicidad de Mentha piperita. Para ello, se desarrolló una revisión integradora de la literatura, cuyas búsquedas se realizaron en las bases de datos VHL (Virtual Health Library), SciELO (Scientific Electronic Library Online) y PubMed, combinando los siguientes descriptores: Mentha piperita; Uso terapéutico; Farmacológico; Compuestos fitoquímicos; y toxicidad. Las 19 producciones científicas seleccionadas evidenciaron el uso terapéutico de M. piperita en la medicina tradicional, contra síntomas respiratorios, digestivos, musculares, dolores nerviosos y prurito. En la medicina moderna, tiene un efecto beneficioso sobre la fibrosis hepática, daño renal, náuseas, vómitos, falta de apetito, actividades cognitivas y fatiga mental. De los diversos componentes fitoquímicos, el mentol y la mentona fueron los más reportados. M. piperita es un antioxidante contra la hepatotoxicidad, renotoxicidad, estrés oxidativo, es regenerador y reparador celular. Además, tiene acción pro-supervivencia sobre nematodos, acción pro-oxidante y efecto de toxicidad sobre larvas de crustáceos. Como propiedades farmacológicas, se destacaron las actividades antimicrobianas, antifúngicas, amebicidas, larvicidas y antiinflamatorias. Desde esta perspectiva, esta herbácea tiene una prometedora aplicación en diversos segmentos científicos y médicos.
Descargas
Citas
AFZAL, S.; AHMAD, H. I.; JABBAR. A.; TOLBA, M. M. et al. Use of Medicinal Plants for Respiratory Diseases in Bahawalpur, Pakistan. BioMed Research International, v. 2021, p. 1-10, 2021.
ALEXA, E.; DANCIU, C.; RADULOV, I.; OBISTIOIU, D. et al. Phytochemical screening and biological activity of Mentha× piperita L. and Lavandula angustifolia mill. extracts. Analytical Cellular Pathology, v. 2018, p. 1-7, 2018.
ANCHISI, C.; MELONI, M. C.; MACCIONI, A. M. Chitosan beads loaded with essential oils in cosmetic formulations. Journal of cosmetic science, v. 57, n. 3, p. 205-214, 2006.
ASHRAFI, B.; RASHIDIPOUR, M.; MARZBAN, A.; SOROUSH, S. et al. Mentha piperita essential oils loaded in a chitosan nanogel with inhibitory effect on biofilm
formation against S. mutans on the dental surface. Carbohydrate polymers, v. 212, p. 142-149, 2019.
BELLASSOUED, K.; HSOUNA, A. B.; ATHMOUNI, K.; VAN PELT, J. et al. Protective effects of Mentha piperita L. leaf essential oil against CCl4 induced hepatic oxidative damage and renal failure in rats. Lipids in health and disease, v. 17, n. 1, p. 1- 14, 2018.
BITTNER FIALOVÁ, S.; KURIN, E.; TRAJ?ÍKOVÁ, E.; JÁNOŠOVÁ, L., et al. Mentha rhizomes as an alternative source of natural antioxidants. Molecules, v. 25, n. 1, p. 200, 2020.
BURT, S. Essential oils: their antibacterial properties and potential applications in foods—a review. International journal of food microbiology, v. 94, n. 3, p. 223-253, 2004.
CAPPELLARI, L. D. R.; SANTORO, M. V.; SCHMIDT, A.; GERSHENZON, J. et al. Improving phenolic total content and monoterpene in Mentha piperita by using salicylic acid or methyl jasmonate combined with Rhizobacteria inoculation. International Journal of Molecular Sciences, v. 21, n. 1, p. 50, 2020.
?AVAR ZELJKOVI?, S.; ŠIŠKOVÁ, J.; KOMZÁKOVÁ, K.; DE DIEGO, N. et al. Phenolic compounds and biological activity of selected Mentha species. Plants, v. 10, n. 3, p. 550, 2021.
DA SILVA RAMOS, R.; RODRIGUES, A. B. L.; FARIAS, A. L. F.; SIMÕES, R. C. et al. Chemical composition and in vitro antioxidant, cytotoxic, antimicrobial, and larvicidal activities of the essential oil of Mentha piperita L. (Lamiaceae). The Scientific World Journal, v. 2017, p. 1-8, 2017.
DE SOUSA, A. A. S.; SOARES, P. M. G.; DE ALMEIDA, A. N. S.; MAIA, A. R. et al. Antispasmodic effect of Mentha piperita essential oil on tracheal smooth muscle of rats. Journal of ethnopharmacology, v. 130, n. 2, p. 433-436, 2010.
DO ESPIRITO SANTO, É.; DE SOUZA, R. B.; LENHARDT, E. H. et al. Screening e avaliação antifúngica do hidrolato e do óleo essencial de Mentha piperita. Visão Acadêmica, v. 21, n. 3, 2020.
DOUROS, A.; BRONDER, E.; ANDERSOHN, F.; KLIMPEL, A. et al. Herb-induced liver injury in the Berlin case-control surveillance study. International journal of molecular sciences, v. 17, n. 1, p. 114, 2016.
ERGÜDEN, C.; ÖZKOÇ, S.; ÖZTÜRK, B.; DELIBA?, B. et al. Investigation of the in vitro effects of Melissa officinalis L., Mentha x piperita L. and Ocimum basilicum L. (Lamiaceae) essential oils on the cysts and trophozoites of Acanthamoeba castellani. Mikrobiyoloji bulteni, v. 50, n. 4, p. 569-579, 2016.
GHAVAMI, M. B.; POORRASTGOO, F.; TAGHILOO, B.; MOHAMMADI, J. et al. Repellency effect of essential oils of some native plants and synthetic repellents against human flea, Pulex irritans (Siphonaptera: Pulicidae). Journal of arthropod-borne diseases, v. 11, n. 1, p. 105-115, 2017.
JAFARIMANESH, H.; AKBARI, M.; HOSEINIAN, R.; ZAREI, M. et al. The effect of peppermint (Mentha piperita) extract on the severity of nausea, vomiting and anorexia in patients with breast cancer undergoing chemotherapy: a randomized controlled trial. Integrative Cancer Therapies, v. 19, p. 1534735420967084, 2020.
JAYAN, L.; PRIYADHARSINI, N.; RAMYA, R.; RAJKUMAR, K. Evaluation of antifungal activity of mint, pomegranate and coriander on fluconazole-resistant Candida glabrata. Journal of oral and maxillofacial pathology: JOMFP, v. 24, n. 3, p. 517-522, 2020.
KENNEDY, D.; OKELLO, E.; CHAZOT, P.; HOWES, M. J. et al. Volatile terpenes and brain function: investigation of the cognitive and mood effects of Mentha× piperita L. essential oil with in vitro properties relevant to central nervous system function. Nutrients, v. 10, n. 8, p. 1029, 2018.
KHERODA DEVI, M.; THANGJAM, I.; SINGH, W. Phytochemical screening of selected twelve medicinal plants commonly used as spices and condiments in manipur, north-east India. International Journal of - Science and Research, v. 8, p. 2945-2947, 2019.
LI, S.; WANG, A.; LIU, L.; TIAN, G. et al. Extraction of polysaccharides under vacuum condition from Lentinus edodes stipe and their antioxidant activities in vitro. Food Science and Biotechnology, v. 28, n. 3, p. 759-767, 2019.
MAHENDRAN, G.; RAHMAN, L. Ethnomedicinal, phytochemical and pharmacological updates on Peppermint (Mentha × piperita L.) - A review. Phytotherapy Research, v. 34, n. 9, p. 2088-2139, 2020.
MARWA, C.; FIKRI-BENBRAHIM, K.; OU-YAHIA, D.; FARAH, A. African peppermint (Mentha piperita) from Morocco: Chemical composition and antimicrobial properties of essential oil. Journal of advanced pharmaceutical technology & research, v. 8, n. 3, p. 86-90, 2017.
MASIERO, M. A.; VIANA, C. M. S. S.; DE LIMA, D. M.; DA SILVA, E. C. et al. Substratos no enraizamento de estacas de Mentha piperita L. Revista Brasileira de Agropecuária Sustentável, v. 10, n. 1, p. 234-240, 2020.
MIMICA-DUKIC, N.; BOZIN, B. Mentha L. species (Lamiaceae) as promising sources of bioactive secondary metabolites. Current Pharmaceutical Design, v. 14, n. 29, p. 3141-3150, 2008.
MOGOSAN, C.; VOSTINARU, O.; OPREAN, R.; HEGHES, C. et al. A comparative analysis of the chemical composition, anti-inflammatory, and antinociceptive effects of the essential oils from three species of Mentha cultivated in Romania. Molecules, v. 22, n. 2-11, p. 263, 2017.
OGALY, H. A.; ELTABLAWY, N. A.; ABD-ELSALAM, R. M. Antifibrogenic influence of Mentha piperita L. essential oil against CCl4-induced liver fibrosis in rats. Oxidative medicine and cellular longevity, v. 2018, p. 1-15, 2018.
PEREIRA, C.; BARROS, L.; FERREIRA, I. C. F. R. Plantas aromáticas usadas como condimentos: prevalência de ácidos gordos polinsaturados. Revista de Ciências Agrárias, v. 40, n. spe, p. 155-159, 2017.
RADAELLI, M.; SILVA, B. P. D.; WEIDLICH, L.; HOEHNE, L. et al. Antimicrobial activities of six essential oils commonly used as condiments in Brazil against Clostridium perfringens. brazilian journal of microbiology, v. 47, p. 424-430, 2016.
RAJKOWSKA, K.; OTLEWSKA, A.; KUNICKA-STYCZY?SKA, A.; KRAJEWSKA, A. Candida albicans impairments induced by peppermint and clove oils at sub-inhibitory concentrations. International journal of molecular sciences, v. 18, n. 1307, p. 1-11, 2017.
SINGH, S. S.; WONG, J. H.; NG, T. B.; SINGH, W. S. et al. Biomedical Applications of Lectins from Traditional Chinese Medicine. Current Protein and Peptide Science, v. 20
SOUZA, G. S.; OLIVEIRA, U. C.; SILVA, J. S.; LIMA, J. C. Crescimento, produção de biomassa e aspectos fisiológicos de plantas de Mentha piperita L. cultivadas sob diferentes doses de fósforo e malhas coloridas. Global Science and Technology, v. 6, n. 3, p. 35-44, 2013.
SOUZA, M. T.; SILVA, M. D.; CARVALHO, R. Revisão integrativa: o que é e como fazer. Einstein (São Paulo), v. 8, p. 102-106, 2010.
SULAIMAN; SHAH, S. M.; SADAF.; AMIM, M.; et al. Ethnoecological, elemental, and phytochemical evaluation of five plant species of lamiaceae in peshawar, Pakistan. Scientifica, v. 2020, p. 1-8, 2020.
UNSAL, V.; CICEK, M.; SABANCILAR, ?. Toxicity of carbon tetrachloride, free radicals and role of antioxidants. Reviews on Environmental Health, v. 36, n. 2, p. 279– 295, 2021.
VIEIRA, L.S. Fitoterapia da Amazônia: Manual de plantas medicinais (a farmácia de Deus). 2.ed. São Paulo: Agronômica Ceres, 1992. 347p.
WU, Z.; TAN, B.; LIU, Y.; DUNN, J. et al. Chemical composition and antioxidant properties of essential oils from peppermint, native spearmint and scotch spearmint. Molecules, v. 24, n. 15, p. 2825, 2019.
, n. 3, p. 220-230, 2019.
Português (Brasil)
English
Español (España)