Potencial osteogénico de células madre mesenquimales sobreexpresión de proteína morfogenética ósea 9
Palabras clave:
Regeneración, Terapia celular, Células madre mesenquimales, Proteína morfogenética óseaResumen
El tejido óseo está compuesto por células capaces de reparar, remodelar y regenerar tejidos, pero que, en grandes proporciones, no presentan resultados satisfactorios. Así, se han evaluado nuevas terapias basadas en la medicina regenerativa con células madre para solucionar el problema. El presente estudio busca evaluar, a través de una revisión integrativa de la literatura, el potencial de formación ósea de la sobreexpresión de la proteína morfogenética ósea 9 (BMP-9) en células madre mesenquimales (MSC). Se trata de un estudio exploratorio, cualitativo y descriptivo. Para su idealización, los descriptores registrados en el DeCS/MeSH “regeneración”, “células madre mesenquimales”, “proteína morfogenética ósea 9” y “factor de diferenciación de crecimiento 2” se vincularon mediante los operadores booleanos “y” y “o” y se aplicaron a las bases de datos de PubMed/Medline, Scielo, Bireme y Google Scholar. De los 142 estudios ubicados en un marco temporal de 10 años (2012 a 2022), 12 artículos publicados en inglés y portugués fueron incluidos en la muestra final. Entre los resultados, estudios in vitro e in vivo muestran que la terapia es prometedora en el proceso de formación de tejido óseo. BMP-9 y CTM aumentaron la potencia de diferenciación de las células en el tejido, lo que permitió la reparación de defectos óseos extensos. Las herramientas tecnológicas de edición de genes han sugerido grandes posibilidades para revolucionar la ciencia, ya que son guías para la escisión del ADN. Son necesarios futuros estudios con enfoque en la terapia celular, para que se profundice científicamente la aplicabilidad de esta técnica y pueda avanzar posteriormente a su uso clínico en las ciencias de la salud.
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Derechos de autor 2023 Zildenilson da Silva Sousa, Thales Peres Candido Moreira, Perilo Marques Chaves Júnior, Ana Carolina da Silva Matias, Valéria Pinto dos Santos, Moysés Matias Mateus, Débora Landim Marques, Samara Evangelista da Silva, José Rafael de Sá Alves, Bruna Damasceno Sá, Michelle Carregosa Andrade
Esta obra está bajo una licencia internacional Creative Commons Atribución 4.0.
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