APLICAÇÕES DOS FLAVONÓIDES EM BIOTECNOLOGIA: PROPRIEDADES TERAPÊUTICAS E APLICAÇÕES NANOTECNOLÓGICAS
DOI:
https://doi.org/10.18816/r-bits.v4i2.5400Resumo
Moléculas bioativas extraídas de plantas têm recebido grande atenção nos últimos anos devido o impacto que as mesmas podem causar na área médica, farmacêutica, no ramo alimentício e outras áreas da biotecnologia. Nesse contexto, os flavonóides destacam-se por estarem presentes em todo o reino vegetal e por apresentarem como sua principal característica a sua atividade antioxidante. Muitos estudos têm avançado na busca de novas propriedades presentes nos flavonóides, e a partir disso várias novas aplicações têm sido propostas para esses compostos. Atualmente sabe-se que além de suas propriedades antioxidantes, diversos outros efeitos biológicos já foram descritos para os flavonóides, tais como: atividade antimicrobiana, antiinflamatória, anticâncer, antitumoral, cardioproteção, antiAlzeimer, neuroprotetora, dentre outras. Diante da enorme aplicabilidade dessas biomoléculas, recentemente a biotecnologia tem proposto diversas novas aplicações para os flavonóides como, por exemplo, na produção de fármacos, biomateriais, sensores e biossensores e ainda em sistemas nanoparticulados para a entrega de drogas. Neste sentido, a presente revisão buscou fazer um apanhado geral da aplicabilidade dos compostos flavonóides dentro da biotecnologia, em especial, nas áreas de saúde e nanotecnologia.
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AHMAD, A.; RAMASAMY, K.; JAAFAR, S. M.; MAJEED A. B. A.; MANI, V. Total isoflavones from soybean and tempeh reversed scopolamine-induced amnesia, improved cholinergic activities and reduced neuroinflammation in brain. Food and Chemical Toxicology, v. 65, p. 120-128, 2014.
AKTAS, O., PROZOROVSKI, T., SMORODCHENKO, A., SAVASKAN, N. E., LAUSTER, R., KLOETZEL, P. M.; INFANTE-DUARTE, C.; BROCKE, S.; ZIPP, F. Green tea epigallocatechin-3-gallate mediates T cellular NF-?B inhibition and exerts neuroprotection in autoimmune encephalomyelitis. The Journal of Immunology, v. 173, n. 9, p. 5794-5800, 2004.
ALCARAZ, L. E.; BLANCO, S. E.; PUIG, O. N.; TOMAS, F.; FERRETTI, F. H. Antibacterial Activity of Flavonoids Against Methicillin-resistant< i> Staphylococcus aureus strains. Journal of Theoretical Biology, v. 205, n. 2, p. 231-240, 2000.
AMBRA, R.; RIMBACH, G.; TERESA, S. P.; FUCHS, D.; WENZEL, U.; DANIEL, H.; VIRGILI. F. Genistein affects the expression of genes involved in blood pressure regulation and angiogenesis in primary human endothelial cells. Nutrition, Metabolism and Cardiovascular Diseases, v. 16, n. 1, p. 35–43, 2006.
AMOROS, M.; SIMOES, C. M.; GIRRE, L.; SAUVAGER, F.; CORMIER, M.. Synergistic effect of flavones and flavonols against herpes simplex virus type 1 in cell culture. Comparison with the antiviral activity of propolis. Journal of Natural Products, v. 55, n. 12, p. 1732–1740, 1992.
ANDRES, A.; DONOVAN, S. M.; KUHLENSCHMIDT, M. S. Soy isoflavones and virus infections. The Journal of nutritional biochemistry, v. 20, n. 8, p. 563-569, 2009.
ARTS, I. C.; JACOBS JR, D. R.; GROSS, M.; HARNACK, L. J.; FOLSOM, A. R. Dietary catechins and cancer incidence among postmenopausal women: the Iowa Women's Health Study (United States).Cancer Causes & Control, v. 13, n. 4, p. 373-382, 2002.
ARTS, M. J. T. J.; HAENEN, G. R. M. M.; VOSS, H. P.; BAST, A. Masking of antioxidant capacity by the interaction of flavonoids with protein. Food and Chemical Toxicology, v. 39, n. 8, p. 787-791, 2001.
BALISTEIRO, D. M.; ROMBALDI, C. V.; GENOVESE, M. I. Protein, isoflavones, trypsin inhibitory and in vitro antioxidant capacities: Comparison among conventionally and organically grown soybeans. Food Research International, v. 51, n. 1, p. 8-14, 2013.
BARREIROS, A. L. B. S.; DAVID, J. M.; DAVID, J. P. Estresse oxidativo: relação entre geração de espécies reativas e defesa do organismo. Química nova, v. 29, n. 1, p. 113, 2006.
BAZYLI?SKA, U.; PUCEK, A.; SOWA, M.; MATCZAK-JON, E.; WILK, K. A. Engineering of phosphatidylcholine-based solid lipid nanocarriers for flavonoids delivery, Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2014.
BORCHARDT, J. R.; WYSE, D. L.; SHEAFFER, C. C.; KAUPPI, K. L.; FULCHER, R. G.; EHLKE, N. J.; BIESBOER, D. D.; BEY, R. F. Antioxidant and antimicrobial activity of seed from plants of the Mississippi river, basin. J. Med. Plants Res, v. 2, p. 81-93, 2008.
BUREAU, G.; LONGPRÉ, F.; MARTINOLI, M. G. Resveratrol and quercetin, two natural polyphenols, reduce apoptotic neuronal cell death induced by neuroinflammation. Journal of neuroscience research, v. 86, n. 2, p. 403-410, 2008.
CAO, J.; XIA, X.; CHEN, X.; XIAO, J.; WANG, Q. Characterization of flavonoids from Dryopteris erythrosora and evaluation of their antioxidant, anticancer and acetylcholinesterase inhibition activities. Food and Chemical Toxicology, v. 51, p. 242–250, 2013.
CASSIDY, A.; MUKAMAL, K. J.; LIU, L.; FRANZ, M.; ELIASSEN, A. H.; RIMM, E. B. High anthocyanin intake is associated with a reduced risk of myocardial infarction in young and middle-aged women. Circulation, v. 127, n. 2, p. 188-196, 2013.
CASSIDY, A.; RIMM, E. B.; O'REILLY, É. J.; LOGROSCINO, G.; KAY, C.; CHIUVE, S. E.; REXRODE, K. M. Dietary flavonoids and risk of stroke in women. Stroke, v. 43, n. 4, p. 946-951, 2012.
CHACHA, M.; BOJASE-MOLETA, G.; MAJINDA, R. R. T. Antimicrobial and radical scavenging flavonoids from the stem wood of Erythrina latissima. Phytochemistry, v. 66, n. 1, p. 99-104, 2005.
BIYITI, L.; PESANDO, D.; PUISEUX-DAO, S. Antimicrobial activity of two flavanones isolated from the Cameroonian plant Erythrina sigmoidea. Planta medica, v. 54, n. 02, p. 126-128, 1988.
CHEN, L.; DING, L.; YU, A.; YANG, R.; WANG, X.; LI, J.; JIN, H.; ZHANG, H. Continuous determination of total flavonoids in Platycladus orientalis (L.) Franco by dynamic microwave-assisted extraction coupled with on-line derivatization and ultraviolet–visible detection Original Research Article, Analytica Chimica Acta, v. 596, n. 1, p. 164-170, 2007.
CHEN, Z.; TAN, J.; YANG, G.; MIAO, M.; CHEN, Y.; LI, T. Isoflavones from the roots and stems of Nicotiana Tabacum and their anti-tobacco mosaic virus activities, Phytochemistry Letters, v. 5, n. 2 , p. 233-235, 2012.
CHENG, M. M.; CUDA, G.; BUNIMOVICH, Y. L.; GASPARI, M.; HEALTH, J. R.; HILL, H. D.; MIRKIN, C. A.; NIJDAM, A. J.; TERRACCIANO, R.; THUNDAT, T.; FERRARI, M. Nanotechnologies for biomolecular detection and medical diagnostics, Curr. Opin. Chem. Biol, v. 10, p. 11-19, 2006.
CHIANG, L. C.; CHIANG, W.; LIU, M.C.; LIN, C. C. In vitro antiviral activities of Caesalpinia pulcherrima and its related flavonoids. Journal of Antimicrobial Chemotherapy, v. 52, n. 2, p. 194-198, 2003.
CHIOU, A.; PANAGOPOULOU, E. A.; GATZALI, F.; DE MARCHI, S.; KARATHANOS, V. T. Anthocyanins content and antioxidant capacity of Corinthian currants (Vitis vinifera L., var. Apyrena). Food chemistry, v. 146, p. 157-165, 2014.
CHO, N.; CHOI, J. H.; YANG, H.; JEONG, E. J.; LEE, K. Y.; KIM, Y. C.; SUNG, S. H. Neuroprotective and anti-inflammatory effects of flavonoids isolated from Rhus verniciflua in neuronal HT22 and microglial BV2 cell lines. Food and Chemical Toxicology, v. 50, n.6, p. 1940–1945, 2012.
CHU, Y. F.; LIU, R. H. Cranberries inhibit LDL oxidation and induce LDL receptor expression in hepatocytes. Life sciences, v. 77, n. 15, p. 1892-1901, 2005.
CHUNG, J.; NGUYEN, A.-K.D, HENSTRIDGE, D. C.; HOLMES, A. G.; CHAN, M. H. S.; MESA, J. L.; LANCASTER, G. I.; SOUTHGATE, R. J.; BRUCE, C. R.; DUFFY, S. J.; HORVATH, I.; MESTRIL, R.; WATT, M. J.; HOOPER, P. L.; KINGWELL, B. A.; VIGH, L.; HEVENER, A.; FEBBRAIO, M. A.HSP72 protects against obesity-induced insulin resistance. Proceedings of the National Academy of Sciences, v. 105, n. 5, p. 1739-1744, 2008.
COOKS, N.C.; SAMMAN, S. Flavonoids: chemistry, metabolism, cardioprotective effects, and dietary sources. The Journal of nutritional biochemistry, v. 7, n. 2, p. 66-76, 1996.
CUSHNIE, T. P.; LAMB, A. J. Antimicrobial activity of flavonoids.International journal of antimicrobial agents, v. 26, n. 5, p. 343-356, 2005.
D’ALESSANDRO T. L.; PRASAIN, J.; BENTON, M. R.; BOTTING, N.; MOORE, R.; DARLEY-USMAR, V.; PATEL, R.; BARNES, S. Polyphenols, inflammatory response, and cancer prevention: chlorination of isoflavones by human neutrophils.The Journal of nutrition, v. 133, n. 11, p. 3773S-3777S, 2003
DAS, S.; ROY, P.; MONDAL, S.; BERA, T.; MUKHERJEE, A. One pot synthesis of gold nanoparticles and application in chemotherapy of wild and resistant type visceral leishmaniasis Original Research Article, Colloids and Surfaces B: Biointerfaces, v. 107, p. 27-34, 2013.
DASTIDAR, S. G.; MANNA, A.; KUMAR, K. A.; MAZUMDAR, K.; DUTTA, N. K.; CHAKRABARTY, A. N.; MOTOHASHI, N.; SHIRATAKI, Y. Studies on the antibacterial potentiality of isoflavones. International journal of antimicrobial agents, v. 23, n. 1, p. 99-102, 2004.
DENG, Y.; LEE, J. P.; TIANASOA-RAMAMONJY, M.; SNYDER, J. K.; DES ETAGES, S. A.; KANADA, D.; SNYDER, M. P.; TURNER, C. J. New antimicrobial flavanones from Physena madagascariensis. Journal of natural products, v. 63, n. 8, p. 1082-1089, 2000.
EBRAHIMI, A.; SCHLUESENER, H. Natural polyphenols against neurodegenerative disorders: potentials and pitfalls, Ageing Res. Rev., v. 11, p. 329–345, 2012.
EGERT, S.; RIMBACH, G. Which sources of flavonoids: complex diets or dietary supplements?, Adv. Nutr., v. 2, p. 8–14, 2011.
EID, H. M.; MARTINEAU, L. C.; SALEEM, A.; MUHAMMAD, A.; VALLERAND, D.; BENHADDOU?ANDALOUSSI, A.; NISTOR L.; AFSHAR, A.; ARNASON, J. T.; HADDAD, P. S. Stimulation of AMP?activated protein kinase and enhancement of basal glucose uptake in muscle cells by quercetin and quercetin glycosides, active principles of the antidiabetic medicinal plant Vaccinium vitis?idaea. Molecular nutrition & food research, v. 54, n. 7, p. 991-1003, 2010.
FANG, Y. Z.; YANG, S.; WU, G. Free radicals, antioxidants, and nutrition. Nutrition, v. 18, n. 10, p. 872-879, 2002.
FERRAZZANO, G. F.; AMATO, I.; INGENITO, A.; ZARRELLI, A.; PINTO, G.; POLLIO, A. Plant polyphenols and their anti-cariogenic properties: a review, Molecules, v. 16, p. 1486–1507, 2011.
FORMICA, J. V.; REGELSON, W. Review of the biology of quercetin and related bioflavonoids. Food and Chemical Toxicology, v. 33, n. 12, p.1061–1080, 1995.
FOTI, P.; ERBA, D.; RISO, P.; SPADAFRANCA, A.; CRISCUOLI, F.; TESTOLI, G. Comparison between daidzein and genistein antioxidant activity in primary and cancer lymphocytes. Archives of biochemistry and biophysics, v. 433, n. 2, p. 421-427, 2005.
FREITAS, K. H. G.; FATIBELLO-FILHO, O.; MATTOS, I. L. D. Square-wave voltammetric determination of rutin in pharmaceutical formulations using a carbon composite electrode modified with copper (II) phosphate immobilized in polyester resin, Braz. J. Pharm. Sci., v. 48, p. 639, 2012.
FUGH-BERMAN, A.; MYERS, A. Citrus aurantium an ingredient of dietary supplements marketed for weight loss: current status of clinical and basic research, Experimental Biology and Medicine. v. 229, n. 8, p. 698 – 704, 2004.
FUJII, H.; NAKAGAWA, T.; NISHIOKA, H.; SATO, E.; HIROSE, A.; UENO, T.; SUN , B.; YOKOZAWA, T.; NONAKA, G-I. Preparation, characterization, and antioxidative effects of oligomeric proanthocyanidin-L-cysteine complexes. Journal of agricultural and food chemistry, v. 55, n. 4, p. 1525-1531, 2007.
FUKUI, H.;GOTO, K.; TABATA, M. Two antimicrobial flavanones from the leaves of Glycyrrhiza glabra. Chem Pharm Bull (Tokyo),v. 36, p. 4174–4176, 1988.
GAO, X.; CASSIDY, A.; SCHWARZSCHILD, M. A.; RIMM, E. B.; ASCHERIO, A. Habitual intake of dietary flavonoids and risk of Parkinson disease. Neurology, v. 78, n. 15, p. 1138-1145, 2012.
GARCIA, A.; BOCANEGRA-GARCIA, V.; PALMA-NICOLAS, J. P.; RIVERA, G. Recent advances in antitubercular natural products, Eur. J. Med. Chem., v. 49, p. 1–23, 2012.
GARCÍA-TIRADO, J.; RIEGER-REYES, C.; SAZ-PEIRO, P. Efecto de los flavonoides en la prevención del cáncer de pulmón: revisiónsistemática. Medicina Clínica, n. 139, v.8, p. 358–363, 2012.
GHOSH, A.; TUDU, B.; TAMULY, P.; BHATTACHARYYA, N.; BANDYOPADHYAY, R. Prediction of theaflavin and thearubigin content in black tea using a voltammetric electronic tongue, Chemometrics and Intelligent Laboratory Systems, v. 116, p. 57-66, 2012.
GUO, H.; XIA, M.; ZOU, T.; LING, W.; ZHONG, R.; ZHANG, W. Cyanidin 3-glucoside attenuates obesity-associated insulin resistance and hepatic steatosis in high-fat diet-fed and< i>db/db mice via the transcription factor FoxO1. The Journal of nutritional biochemistry, v. 23, n. 4, p. 349-360, 2012.
HAGHIA C. M.; WALLE, T. Quercetin induces necrosis and apoptosis in SCC-9 oral cancer cells. Nutrition and Cancer, n. 53 v.2, p.220–231, 2005.
HALLIWELL, B. Drug antioxidant effects. Drugs, v. 42, n. 4, p. 569-605, 1991.
HAN, K.C.; WONG, W.C.; BENZIE, I. F. Genoprotective effects of green tea (Camellia sinensis) in human subjects: results of a controlled supplementation trial. British Journal of Nutrition, v. 105, n. 2, p. 171–179, 2011.
HARBORNE, J. B.; WILLIAMS, C. A. Advances in favonoid research since 1992. Phytochemistry, v. 55, n. 6, p. 481-504, 2000.
HAYASHI, K.; HAYASHI, T.; OTSUKA, H.; TAKEDA, Y. Antiviral activity of 5,6,7-trimethoxyflavone and its potentiation of the antiherpes activity of acyclovir.Journal of Antimicrobial Chemotherapy, v. 39, n. 6,p. 821–824, 1997.
HE, J. B.; JIN, G. P.; CHEN, Q. Z.; WANG, Y. A quercetin modified biosensor for amperometric determination of uric acid in the presence of ascorbic acid, Anal. Chim. Acta, v. 585, p. 337–343, 2007.
HENDRIKS, J. J.; ALBLAS, J.; VAN DER POL, S. M.; VAN TOL, E. A.; DIJKSTRA, C. D.; DE VRIES, H. E.Flavonoids influence monocytic GTPase activity and are protective in experimental allergic encephalitis. The Journal of experimental medicine, v. 200, n. 12, p. 1667-1672, 2004.
HERTOG, M. G.; FESKENS, E. J.; HOLLMAN, P. C.; KATAN, M. B.; KROMHOUT, D. Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen elderly Study. Lancet, v. 342, n. 8878, p. 1007–1011, 1993.
HILLMAN, G. G.; SINGH-GUPTA, V.; HOOGSTRA, D. J.; ABERNATHY, L.; RAKOWSKI, J.; YUNKER, C. K.; ROTHSTEIN, S. E.; SARKAR, F .H.; GADGEEL, S.; KONSKI, A. A.; LONARDO, F.; JOINER, M. C. . Differential effect of soy isoflavones in enhancing high intensity radiotherapy and protecting lung tissue in a pre-clinical model of lung carcinoma. Radiotherapy and Oncology, v. 109, n. 1, p. 117-125, 2013.
HILLMAN, G. G.; SINGH-GUPTA, V.; RUNYAN, L.; YUNKER, C. K.; RAKOWSKI, J. T..; SARKAR, F. H.; MILLER, S.; GADGEEL, S. M.; SETHI, S.; JOINER, M. C.; KONSKI, A. A. Soy isoflavones radiosensitize lung cancer while mitigating normal tissue injury. Radiotherapy and Oncology, v. 101, n. 2, p. 329-336, 2011.
HOU, D-X. Potential mechanisms of cancer chemoprevention by anthocyanins. Current molecular medicine, v. 3, n. 2, p. 149-159, 2003.
HUFFORD, C. D.; LASSWELL JR, W. L. Antimicrobial activities of constituents of Uvaria chamae. Lloydia, v. 41, n. 2, p. 156-160, 1977.
HWANG, S. L.; SHIH, P. H.; YEN, G. C. Neuroprotective effects of citrus flavonoids. Journal of Agricultural and Food Chemistry, v. 60, n. 4, p. 877–885, 2012.
IMHOF, M.; MOLZER, S.; IMHOF, M. Effects of soy isoflavones on 17?-estradiol-induced proliferation of MCF-7 breast cancer cells. Toxicology in Vitro, v. 22, n. 6, p. 1452-1460, 2008.
ISLAM, N.; MIYAZAKI, K. Nanotechnology innovation system: Understanding hidden dynamics of nanoscience fusion trajectories, Technological Forecasting and Social Change, v. 76, p. 128-140, 2009.
JANG, Y. P.; ZHOU, J.; NAKANISHI, K.; SPARROW, J. R. Anthocyanins Protect Against A2E Photooxidation and Membrane Permeabilization in Retinal Pigment Epithelial Cells. Photochemistry and photobiology, v. 81, n. 3, p. 529-536, 2005.
JENNINGS, A.; WELCH, A. A.; FAIRWEATHER-TAIT, S. J.; KAY, C.; MINIHANE, A. M.; CHOWIENCZYK, P.; JIANG, B.; CECELJA, M.; SPECTOR, T.; MACGREGOR, A.; CASSIDY, A. Higher anthocyanin intake is associated with lower arterial stiffness and central blood pressure in women. The American journal of clinical nutrition, v. 96, n. 4, p. 781-788, 2012.
JEON, S-M.; PARK, Y. B.; CHOI, M-S. Antihypercholesterolemic property of naringin alters plasma and tissue lipids, cholesterol-regulating enzymes, fecal sterol and tissue morphology in rabbits.Clinical nutrition, v. 23, n. 5, p. 1025-1034, 2004.
JEON, W. K.; LEE, J. H.; KIM, H. K.; LEE, A. Y.; LEE, S. O.; KIM, Y. S.; RYU, S. Y.; KIMC, S. Y.; LEED, Y. J.; KO, B. S. Anti-platelet effects of bioactive compounds isolated from the bark ofRhus verniciflua Stokes. Journal of ethnopharmacology, v. 106, n. 1, p. 62-69, 2006.
JUNG, H. A.; JIN, S. E.; MIN, B. S.; KIM, B. W.; CHOI, J. S. Anti-inflammatory activity of Korean thistle Cirsium maackii and its major flavonoid, luteolin 5-O-glucoside. Food and Chemical Toxicology, v. 50, n. 6, p. 2171-2179, 2012.
JUNG, U. J.; KIM, H. J.; LEE, J. S.; LEE, M. K.; KIM, H. O.; PARK, E. J.; KIM, H. K.; JEONG, T. S.; CHO, M. S. Naringin supplementation lowers plasma lipids and enhances erythrocyte antioxidant enzyme activities in hypercholesterolemic subjects. Clinical Nutrition, v. 22, n. 6, p. 561-568, 2003.
JUNG, U. J.; LEE, M-K.; PARK, Y.B.; KANG, M. A.; CHOI, M-S. Effect of citrus flavonoids on lipid metabolism and glucose-regulating enzyme mRNA levels in type-2 diabetic mice. The international journal of biochemistry & cell biology, v. 38, n. 7, p. 1134-1145, 2006.
KAMARA J, S.; VINODHKUMAR, R.; ANANDAKUMAR, P.; JAGAN, S.; RAMA-KRISHNAN, G.; DEVAKI, T. The effects of quercetin on antioxidante status and tumor markers in the lung and sérumof mice treated with benzo (a) pyrene. Biological and pharmaceutical bulletin, v. 30, n. 12, p. 2268–73, 2007.
KANG, J. W.; ZHUO, L.; LU, X. Q.; WANG, X. Q. Electrochemical behavior of dopamine at a quercetin-SAM-modified gold electrode and analytical application, J. Solid State Electrochem, v. 9, p. 114–120, 2005.
KATSUBE, N.; IWASHITA, K.; TSUSHIDA, T.; YAMAKI, K.;KOBORI, M. Induction of apoptosis in cancer cells by bilberry (Vaccinium myrtillus) and the anthocyanins. Journal of agricultural and food chemistry, v. 51, n. 1, p. 68-75, 2003.
KHAN, N.; AFAQ, F.; MUKHTAR, H. Cancer chemoprevention through dietary antioxidants: progress and promise. Antioxidants & redox signaling, v. 10, p. 475–510, 2008.
KHAN, N.; MUKHTAR, H. Cancer and metastasis: prevention and treatment by green tea. Cancer and Metastasis Reviews, v. 29, n. 3, p. 435-445, 2010.
KIM, H. J.; OH, G. T.; PARK, Y. B.; LEE, M. K.; SEO, H. J.; CHOI, M. S. Naringin alters the cholesterol biosynthesis and antioxidant enzyme activities in LDL receptor-knockout mice under cholesterol fed condition. Life sciences, v. 74, n. 13, p. 1621-1634, 2004.
KIM, J. T.; LEE, W. S.; KIM, Y.S.; CURTIS-LONG, M. J.; LEE, B. W.; RYU, Y. B.; PARK, K. H. Isolation of cholinesterase-inhibiting flavonoids from Morus lhou. Journal of agricultural and food chemistry, v. 59, n. 9, p. 4589-4596, 2011.
KIM, M-H; KANG, K-S. Isoflavones as a smart curer for non-alcoholic fatty liver disease and pathological adiposity via ChREBP and Wnt signaling. Preventive medicine, v. 54, p. S57-S63, 2012.
Kiokias, s.; Varzakas, t. Activity of flavonoids and ?-carotene during the auto-oxidative deterioration of model food oil-in water emulsions. Food Chemistry, v.150, p. 280–286, 2014.
KONAN, N. A.; LINCOPAN, N.; COLLANTES DÍAZ, I. E.; JACYSYN, J. F.; TIBA, M. M. T.; MENDES, J. G. P. A.; BACCHID, E. M.; SPIRA, B. Cytotoxicity of cashew flavonoids towards malignant cell lines. Experimental and Toxicologic Pathology, v. 64, n. 5, p. 435-440, 2012.
KONGKUMA, N.; TUCHINDAA, P.; POHMAKOTRA, M.; REUTRAKULA, V.; PIYACHATURAWATB, P.; JARIYAWATB, S.; SUKSENB, K.; YOOSOOKC, C.; KASISITC, J.; NAPASWADC, C. DNA topoisomerase II? inhibitory and anti-HIV-1 flavones from leaves and twigs of Gardenia carinata.Fitoterapia, v. 83, n. 2, p. 368–372, 2012.
KUROYANAGI, M.; ARAKAWA, T.; HIRAYAMA, Y.; HAYASHI, T. Antibacterial and Antiandrogen Flavonoids from Sophora f lavescens. Journal of natural products, v. 62, n. 12, p. 1595-1599, 1999.
KURZAWA-ZEGOTA, M.; NAJAFZADEH, M.; BAUMGARTNER, A.; ANDERSON, D. The protective effect of the flavonoids on food-mutagen-induced DNA damage in peripheral blood lymphocytes from colon cancer patients. Food and chemical toxicology, v. 50, n. 2, p. 124-129, 2012.
LAGIOU, P.; SAMOLI, E.; LAGIOU, A.; TZONOU, A.; KALANDIDI, A.; PETERSON, J.; DWYE, J.; TRICHOPOULOS, D. Intake of specific flavonoid classes and coronary heart disease: a case-control study in Greece. European Journal of Clinical Nutrition, v. 58, n. 12, p. 1643–1648, 2004a.
LAGIOU, P.; SAMOLI, E.; LAGIOU, A.; PETERSON, J.; TZONOU, A.; DWYER, J.; TRICHOPOULOS, D. Flavonoids, vitamin C and adenocarcinoma of the stomach. Cancer Causes & Control, v. 15, n.1, p. 67–72, 2004b.
LEE, J. C.; LIM, K. T.; JANG, Y. S. Identification of Rhus verniciflua Stokes compounds that exhibit free radical scavenging and anti-apoptotic properties. Biochimica et Biophysica Acta (BBA) - General Subjects, v. 1570, n.3, p. 181-191, 2002.
LEE, Y-R.; LEEA, Y. R.; HWANGB, J. K.; KOHB, H. W.; JANGC, K. Y.; LEED, J. H,; PARKB, J. W.; PARK, B. H. Sulfuretin, a major flavonoid isolated from Rhus verniciflua, ameliorates experimental arthritis in mice. Life sciences, v. 90, n. 19, p. 799-807, 2012.
LIANG, W.; LEE, A. H.; BINNS, C. W.; HUANG, R.; HU, D.; SHAO, H. Soy consumption reduces risk of ischemic stroke: a case-control study in Southern China. Neuroepidemiology, v. 33, n. 2, p. 111-116, 2009.
LIN, X. Q.; HE, J. B.; ZHA, Z. G. Simultaneous determination of quercetin and rutin at a multi-wall carbon-nanotube paste electrodes by reversing differential pulse voltammetry, Sens. Actuators B Chem., v. 119, p. 608, 2006.
LIU, S.; LUO, X.; LI, D.; ZHANG, J.; QIU, D.; LIU, W.; SHE, L.; YANG, Z. Tumor inhibition and improved immunity in mice treated with flavone from Cirsium japonicum DC. International Immunopharmacology, v. 6, n. 9, p. 1387-1393, 2006.
LIU, X. H.; LIU, H. F.; SHEN, X.; SONG, B. A.; BHADURY, P. S.; ZHU, H. L. Synthesis and molecular docking studies of novel 2-chloro-pyridine derivatives containing flavone moieties as potential antitumor agents.Bioorganic & Medicinal Chemistry Letters, v. 20, n. 14, p. 4163-4167, 2010.
LU, J.; PAPP, L.V.; FANG, J.; RODRIGUEZ-NIETO, S.; ZHIVOTOVSKY, B.; HOLMGREN, A . Inhibition of mammalian thioredoxin reductase by some flavonoids: implications for myricetin and quercetin anticancer activity. Cancer Research, v. 66, n. 8, p. 4410-4418, 2006.
LUO, C.; ZOU, X.; LI, Y.; SUN, C.; JIANG, Y.; WU, Z. Determination of flavonoids in propolis-rich functional foods by reversed phase high performance liquid chromatography with diode array detection , Food Chemistry, v. 127, n. 1, p. 314-320, 2011.
MAGNUSZEWSKA , J.; KROGULEC, T. Application of hot platinum microelectrodes for determination of flavonoids in flow injection analysis and capillary electrophoresis. Analytica Chimica Acta, v. 786, p. 39–46, 2013.
MAHMOUD, A. M.; YANGA, W.; BOSLAND, M. C. Soy isoflavones and prostate cancer: A review of molecular mechanisms. The Journal of Steroid Biochemistry and Molecular Biology, v. 140, p. 116–132, 2014.
MAHMOUD, A; ASHOUR, M. B; ABDEL-MONEIM, A.; AHMED, O. M. Hesperidin and naringin attenuate hyperglycemia-mediated oxidative stress and proinflammatory cytokine production in high fat fed/streptozotocin-induced type 2 diabetic rats. Journal of Diabetes and its Complications, v. 26, n. 6, p. 483-490, 2012.
MANACH, C.; SCALBERT, A.; MORAND, C.; RÉMÉSY, C.; JIMÉNEZ, L. Polyphenols: food sources and bioavailability. The American journal of clinical nutrition, v. 79, n. 5, p. 727-747, 2004.
MARCCHO, J. H.; LEE, J. G.; YANG, Y.I.; KIM, J. H.; AHN, J. H.; BAEK, N. I.; LEE, K. T.; CHOI, J. H. Eupatilin, a dietary flavonoid, induces G2/M cell cycle arrest in human endometrial cancer cells. Food and Chemical Toxicology, v. 49, n. 8, p. 1737-1744, 2011.
MARKHAM, K. R.; PORTER, L. J. Flavonoids in the green algae(Chlorophyta). Phytochemistry, v. 8, n. 9, p. 1777-1781, 1969.
MARTENS, S.; MITHÖFER, A. Flavones and flavone synthases. Phytochemistry. v. 66, n. 20, p. 2399–2407, 2005.
MARTIN, P. M.; HORWITZ, K. B.; RYAN, D. S.; MCGUIRE, W. L. Phytoestrogen interaction with estrogen receptors in human breast câncer cells. Endocrinology, v. 103, p.1860–1867, 1978.
MENG, H-C.; ma, c-m. Flavan-3-ol-cysteine and acetylcysteine conjugates from edible reagents and the stems of Cynomorium songaricum as potent antioxidants. Food chemistry, v. 141, n. 3, p. 2691-2696, 2013.
MENGA, Q.; HANB, T.; WANGC, G.; ZHENGA, N.; CAOA, C.; XIEA, S. Preparation of a natural dye doped Ormosil coating for the detection of formaldehyde in the optical gas sensor, Sensors and Actuators B: Chemical, v. 196, p. 238–244, 2014.
MIDDLETON JR, E. Effect of Plant Flavonoids on Immune and Inflammatory Cell Function. Advances in Experimental Medicine and Biology. v. 439, p, 175-182, 1998.
MIDDLETON JR, E.; KANDASWAMI, C. Effects of flavonoids on immune and inflammatory cell functions. Biochemical Pharmacology, n.43, v. 6, p. 1167–1179, 1992.
MOTTRAM, T.; HART, J.; PEMBERTON, R. A sensor based automatic ovulation prediction system for dairy cows, Proceedings of 5th AISEM Conference, 2000.
MUTHIAN, G.; BRIGHT, J. J. Quercetin, a flavonoid phytoestrogen, ameliorates experimental allergic encephalomyelitis by blocking IL-12 signaling through JAK-STAT pathway in T lymphocyte. Journal of Clinical Immunology, v. 24, n. 5, p. 542-552, 2004.
NISHINO, C.; ENOKI, N.; TAWATA, S.; MORI, A.; KOBAYASHI, K.; FUKUSHIMA, M. Antibacterial Activity of Flavonoids against Staphylococcus epidermidis, a Skin Bacterium (Organic Chemistry). Agricultural and biological chemistry, v. 51, n. 1, p. 139-143, 1987.
NIU, T. Z.; ZHANG, Y. W.; BAO, Y. L.; WU, Y.; YU, C. L.; SUN, L. G.; YI, J. W.; HUANG, Y. X.; LI, Y. X. A validated high-performance liquid chromatography method with diode array detection for simultaneous determination of nine flavonoids in Senecio cannabifolius Less, Journal of Pharmaceutical and Biomedical Analysis, v. 76, p. 44–48, 2013.
NOONAN, D. M.; BENELLI, R.; ALBINI. A. Angiogenesis and cancer prevention: a vision. Cancer Prevention, v. 174, p. 219–224, 2007.
NOVAK, I.; JANEIRO, P.; SERUGA, M.; OLIVEIRA-BRETT, A. M. Ultrasound extracted flavonoids from four varieties of Portuguese red grape skins determined by reverse-phase high-performance liquid chromatography with electrochemical detection, Analytica Chimica Acta, v. 630, n. 2, p. 107–115, 2008.
OMONI, A. O.; ALUKO, R. E.Soybean foods and their benefits: potential mechanisms of action. Nutrition reviews, v. 63, n. 8, p. 272-283, 2005.
ORTSATER, H.; GRANKVIST, N.; WOLFRAM, S.; KUEHN, N.; SJOHOLM, A. Diet supplementation with green tea extract epigallocatechin gallate prevents progression to glucose intolerance in db/db mice. Nutrition & Metabolism, v. 9, n. 11, 2012.
PAL, R.; PANIGRAHI, S.; BHATTACHARYYA, D.; CHAKRABORTI, A. S. Characterization of citrate capped gold nanoparticle-quercetin complex: Experimental and quantum chemical approach, Journal of Molecular Structure, v. 1046, p. 153–163, 2013.
PARK, Y. J.; KIM, H. J.; LEE, S. J.; CHOI, H. Y.; JIN, C.; LEE, Y. S. A new chromone, 11-hydroxy-sec-O-glucosylhamaudol from Ostericum koreanum. Chemical & pharmaceutical bulletin, v. 55, n. 7, p. 1065-1066, 2007.
PETERSON, J.; LAGIOU, P.; SAMOLI, E.; LAGIOU, A.; KATSOUYIANNI, K.; LA VECCIA, C.; DWYE, J.; TRICHOPOULOS, D. Flavonoid intake and breast cancer risk: a case-control study in Greece. British Journal of Cancer, v. 89, n.7, p. 1255–1259, 2003.
PIETTA, P-G. Flavonoids as antioxidants. Journal of natural products, v. 63, n. 7, p. 1035-1042, 2000.
QUINTON R. D. J.; WARFORD J.; RUPASINGHE H. P. V.; ROBERTSON, G. S. Target-based selection of flavonoids for neurodegenerative disorders. Trends in pharmacological sciences, v. 33, n. 11, p. 602-610, 2012.
RAMOS, S. Effects of dietary flavonoids on apoptotic pathways related to cancer chemoprevention. The Journal of nutritional biochemistry, v. 18, n. 7, p. 427–442, 2007.
RAOOF, J. B.; OJANI, R.; AMIRI-AREF, M.; BAGHAYERI, M. Electrodeposition of quercetin at a multi-walled carbon nanotubes modified glassy carbon electrode as a novel and efficient voltammetric sensor for simultaneous determination of levodopa, uric acid and tyramine, Sensors and Actuators B: Chemical, v. 166–167, p. 508–518, 2012.
RAUHA, J. P.; REMES, S.; HEINONEN, M.; HOPIA, A.; KÄHKÖNEN, M.; KUJALA, T.; PIHLAJAC, K.; VUORELAA, H.; VUORELA, P. Antimicrobial effects of Finnish plant extracts containing flavonoids and other phenolic compounds. International journal of food microbiology, v. 56, n. 1, p. 3-12, 2000.
RÉVÉSZ, K.; TÜTT?, A.; SZELÉNYI, P.; KONTA, L. Tea flavan-3-ols as modulating factors in endoplasmic reticulum function, Nutrition Research. V. 31, n. 10, p. 731–740, 2011.
RIDNOUR, L. A.; THOMAS, D. D.; MANCARDI, D.; ESPEY, M. G.; MIRANDA, K; M.; PAOLOCCI, N.; FEELISCH, M.; FUKUTO, J.; WINK, D. A. The chemistry of nitrosative stress induced by nitric oxide and reactive nitrogen oxide species. Putting perspective on stressful biological situations. Biological chemistry, v. 385, n. 1, p. 1-10, 2004.
RIJKE, E. D.; OUT, P.; NIESSEN, W. M. A.; ARIESE, F.; GOOIJER, C.; BRINKMAN, U. A. T., Analytical separation and detection methods for flavonoids, Journal of Chromatography A, v. 1112, n. 1–2, p. 31–63, 2006.
ROBIN, V.; IRURZUN, A.; AMOROS, M.; BOUSTIE, J.; CARRASCO, L. Antipoliovirus flavonoids from Psiadia dentata. Antiviral Chem Chemother, v. 12, p. 283–291, 2001.
RUIZ-LARREA, M. B.; MOHAN, A. R.; PAGANGA, G; MILLER, N. J.; BOLWELL, G. P.; RICE-EVANS, C. A. Antioxidant activity of phytoestrogenic isoflavones. Free radical research, v. 26, n. 1, p. 63-70, 1997.
SAHINER, N. One step poly(quercetin) particle preparation as biocolloid and its characterization. Colloids and Surfaces A: Physicochemical and Engineering Aspects, v. 452, p. 173-180, 2014.
SAHOO, S. K.; PARVEEN, S. PANDA, J. J. The present and future of nanotechnology in human health care. Nanomedicine, v. 1, p. 20-31, 2007.
SALMI, Z.; BENMEHDI, H.; LAMOURI, A.; DECORSE, P.; JOUINI, M.; YAGCI et al. Preparation of MIP grafts for quercetin by tandem aryl diazonium surface chemistry and photopolymerization. Microchim. Acta, v. 180, p. 1411, 2013.
SEO, H-J.; JEONG, K. S.; LEE, M-K.; PARK, Y. B.; JUNG, U. J.; KIM, H-J.; CHOI M-S. Role of naringin supplement in regulation of lipid and ethanol metabolism in rats. Life sciences, v. 73, n. 7, p. 933-946, 2003.
SHARMA, A. K.; BHARTI, S.; OJHA, S.; BHATIA, J.; KUMAR, N.; RAY; R.; KUMARI, S.; ARYA, D. S. Up-regulation of PPAR g, heat shock protein-27 and-72 by naringin attenuates insulin resistance, b-cell dysfunction, hepatic steatosis and kidney damage in a rat model of type 2 diabetes. British Journal of Nutrition, v. 106, n. 11, p. 1713-23, 2011.
SIEDLER, S.; STAHLHUT, S. G.; MALLA, S.; MAURY, J.; NEVES, A. R. Novel biosensors based on flavonoid-responsive transcriptional regulators introduced into Escherichia coli, Metabolic Engineering, v. 21, p. 2–8, 2014.
SIMS, M. J.; LI, Q.; KACHOOSANGI, R. T.; WILDGOOSE, G. G.; COMPTON, R. G. Using multiwalled carbon nanotube modified electrodes for the adsorptive striping voltammetric determination of hesperidin, Electrochimica Acta, v. 54, n. 22, p. 5030–5034, 2009.
SMITH, A. J.; KAVURU, P.; WOJTAS, L.; ZAWOROTKO, M. J.; SHYTLE, R. D. Cocrystals of quercetin with improved solubility and oral bioavailability, Mol. Pharm., v. 8, p. 1867–1876, 2011.
SMITH, C.; HALLIWELL, B.; ARUOMA, O. Protection by albumin against the pro-oxidant actions of phenolic dietary components. Food and Chemical Toxicology, v. 30, n. 6, p. 483-489, 1992.
SOWA, M.; ?LEPOKURA, K.; MATCZAK-JON, E. Cocrystals of fisetin, luteolin and genistein with pyridinecarboxamide coformers: crystal structures, analysis of intermolecular interactions, spectral and thermal characterization, CrystEngComm., v. 15, p. 7696–7708, 2013.
STANTCHEV, T. S.; MARKOVIC, I.; TELFORD, W. G.; CLOUSE, K. A.; BRODER, C. C. The tyrosine kinase inhibitor genistein blocks HIV-1 infection in primary human macrophages. Virus Research, v. 123, n. 2, p.178–189, 2007.
SUN, D.; DONG, L.; GUO, P.; SHI, X.; GAO, J.; REN, Y.; JIANG, X.; LI, W.; WANG, C.; WANG, Q. Simultaneous detection of flavonoids and phenolic acids in Herba Lysimachiae and Herba Desmodii Styracifolii using liquid chromatography tandem mass spectrometry, Food Chemistry, v. 138, n. 1, p. 139–147, 2013.
SUN, Q., ZHENG, Y.; ZHANG, X.; HU, X.; WANG, Y.; ZHANG, S.; ZHANG, D.; NIE, H. Novel immunoregulatory properties of EGCG on reducing inflammation in EAE. Frontiers in bioscience: a journal and virtual library, v. 18, p. 332-342, 2012.
TAKIKAWA, M.; INOUE, S.; HORIO, F.; TSUDA, T. Dietary anthocyanin-rich bilberry extract ameliorates hyperglycemia and insulin sensitivity via activation of AMP-activated protein kinase in diabetic mice. The Journal of nutrition, v. 140, n. 3, p. 527-533, 2010.
TARAHOVSKY, Y. S.; KIM, Y. A.; YAGOLNIK, E. A.; MUZAFAROV, E. N. Flavonoid–membrane interactions: Involvement of flavonoid–metal complexes in raft signaling, Biochimica et Biophysica Acta (BBA) - Biomembranes, v. 1838, n. 5, p. 1235-1246, 2014.
TARLE, D.; DVORZAK, I. Antimicrobial activity of the plant Cirsium oleraceum (L.) Scop. Acta Pharm Jugosl, v. 40, p. 569–571, 1999.
TERESCHUK, M. L.; RIERA, M. V.; CASTRO, G. R.; ABDALA, L. R. Antimicrobial activity of flavonoids from leaves of Tagetes minuta. Journal of Ethnopharmacology, v. 56, n. 3, p. 227-232, 1997.
TESIO, A. Y.; GRANERO, A. M.; VETTORAZZI, N. R.; FERREYRA, N. F.; RIVAS, G. A.; FERNÁNDEZ, H.; ZON, M. A. Development of an electrochemical sensor for the determination of the flavonoid luteolin in peanut hull samples. Microchemical Journal, v. 115, p. 100–105, 2014.
TOUNY L. H, BANERJEE, P. P. Identification of both Myt-1 and Wee-1 as necessary mediators of the p21-independent inactivation of the cdc-2/cyclin B1 complex and growth inhibition of TRAMP cancer cells by genistein. Prostate, v. 66, n. 14 p. 1542–1555, 2006.
TSUCHIYA, H.; IINUMA, M. Reduction of membrane fluidity by antibacterial sophoraflavanone G isolated from Sophora exigua. Phytomedicine, v. 7, n. 2, p. 161-165, 2000.
TSUDA, T.; WATANABE, M.; OHSHIMA, K.; NORINOBU, S.; CHOI, S. W.; KAWAKISHI, S.; OSAWA, T.Antioxidative activity of the anthocyanin pigments cyanidin 3-O-?-D-glucoside and cyanidin. Journal of Agricultural and Food Chemistry, v. 42, n. 11, p. 2407-2410, 1994.
TSUJI, P. A; WINN, N. R.; WALLE, T. Accumulation and metabolism of the anticancer flavonoid 5,7-dimethoxyflavone compared to its unmethylated analog chrysin in the Atlantic killifish. Chemico-Biological Interactions, v. 164, n. 1, p. 85-92, 2006.
ULIANA, C. V.; GARBELLINI, G. S.; YAMANAKA, H. Electrochemical investigations on the capacity of flavonoids to protect DNA against damage caused by textile disperse dyes. Sensors and Actuators B: Chemical, v. 192, p. 188–195, 2014.
VALSARAJ, R.; PUSHPANGADAN, P.; SMITT, U. W.; ADSERSEN, A.; CHRISTENSEN, S. B.; SITTIE, A.; NYMAN, U.; NIELSEN, C.; OLSEN, C. E. New anti-HIV-1, antimalarial, and antifungal compounds from Terminalia bellerica. Journal of natural products, v. 60, n. 7, p. 739-742, 1997.
VELA, E. M.; BOWICK, G. C.; HERZOG, N. K.; ARONSON, J. F. Genistein treatment of cells inhibits arenavirus infection. Antiviral research, v. 77, n. 2, p. 153-156, 2008.
VENKATACHALAM, H.; YOGENDRA, N.; JAYASHREE, B. S. Synthesis, characterization and antioxidant activities of synthetic chalcones and flavones.APCBEE Procedia, n. 3, p. 209 – 213, 2012.
VOLIKAKIS, G. J.; EFSTATHIOU, C. E. Determination of rutin and other flavonoids by flow-injection/adsorptive stripping voltammetry using nujol-graphite and diphenylether-graphite paste electrodes. Talanta, v. 51, n. 4, p. 775–785, 2000.
WÄCHTER, G. A.; HOFFMANN, J. J.; FURBACHER, T.; BLAKE, M. E.; TIMMERMANN, B. N. Antibacterial and antifungal flavanones from Eysenhardtia texana. Phytochemistry, v. 52, n. 8, p. 1469-1471, 1999.
WALLE, T.; TA, N.; KAWAMORI, T.; WEN, X.; TSUJI, P. A.; WALLE, U. K. Cancer chemopreventive properties of orally bioavailable flavonoids—Methylated versus unmethylated flavones. Biochemical pharmacology, v. 73, n. 9, p. 1288-1296, 2007.
WANG, J.; FERRUZZI, M. G.; HO, L.; BLOUNT, J.; JANLE, E. M.; GONG, B.; PAN, Y.; GOWDA, G. A.; RAFTERY, D.; ARRIETA-CRUZ, I.; SHARMA, V.; COOPER, B.; LOBO, J.; SIMON, J. E.; ZHANG, C.; CHENG, A.; QIAN, X.; ONO, K.; TEPLOW, D. B.; PAVLIDES, C.; DIXON, R. A.; PASINETTI, G.M. Brain-targeted proanthocyanidin metabolites for Alzheimer's disease treatment. The Journal of Neuroscience, v. 32, n. 15, p. 5144-5150, 2012.
WANG, K.; WU, Y.; LI, H.; LI, M.; ZHANG, D.; FENG, H.; FAN, H. Dual-functionalization based on combination of quercetin compound and rare earth nanoparticle Original Research Article. Journal of Rare Earths, v. 31, n. 7, p. 709-714, 2013.
WANG, M.; ZHANG, D.; TONG, Z.; XU, X.; YANG, X. Voltammetric behavior and the determination of quercetin at a flowerlike Co3O4 nanoparticles modified glassy carbon electrode. J. Appl. Electrochem., v. 41, p. 189, 2011.
WANG, W.; HUANG, C. Y.; TSAI, F. J. TSAI, C. C.; YAO, C. H.; CHEN, Y. S. Growth-promoting effects of quercetin on peripheral nerves in rats. The International journal of artificial organs, v. 34, n. 11, p. 1095-1105, 2011.
WEDICK, N. M.; PAN, A.; CASSIDY, A.; RIMM, E. B.; SAMPSON, L.; ROSNER,B.; WILLETT, W.; HU, F. B.; SUN, Q.; DAM, R. M. V. Dietary flavonoid intakes and risk of type 2 diabetes in US men and women. The American journal of clinical nutrition, v. 95, n. 4, p. 925-933, 2012.
WILCOX, L. J.; BORRADAILE, N. M.; DREU, L. E.; HUFF, M. W. Secretion of hepatocyte apoB is inhibited by the flavonoids, naringenin and hesperetin, via reduced activity and expression of ACAT2 and MTP. Journal of lipid research, v. 42, n. 5, p. 725-734, 2001.
WILKO?AZKA, J. A.; RUZGAS, T.; GORTON, L. Use of laccase-modified electrode for amperometric detection of plant flavonoids. Enzyme and Microbial Technology, v. 35, n. 2–3, p. 238–241, 2004.
WILLIAMS, C. Healthy eating: clarifying advice about fruit and vegetables. BMJ, v. 310, p. 1453–1455, 1995.
WILLIAMS, C. M.; EL MOHSEN, M.A..; VAUZOUR, D.; RENDEIRO, C.; BUTLER, L.T.; ELLIS, J. A.; WHITEMAN, M.; SPENCER, J.P. Blueberry-induced changes in spatial working memory correlate with changes in hippocampal CREB phosphorylation and brain-derived neurotrophic factor (BDNF) levels. Free Radical Biology and Medicine, v. 45, n. 3, p. 295-305, 2008.
WILLIAMS, R. J.; SPENCER, J. P.; RICE-EVANS, C. Flavonoids: antioxidants or signalling molecules?. Free Radical Biology and Medicine, v. 36, n. 7, p. 838-849, 2004.
WU, T.; GUAN, Y.; YE, J. Determination of flavonoids and ascorbic acid in grapefruit peel and juice by capillary electrophoresis with electrochemical detection, Food Chemistry, v. 100, n. 4, p. 1573–1579, 2007.
XIAO, J.; MUZASHVILID, T. S.; GEORGIEVE, M. I. Advances in the biotechnological glycosylation of valuable flavonoids. Biotechnology Advances, 2014.
XIAO, P.; ZHAO, F.; ZENG, B. Voltammetric determination of quercetin at a multi-walled carbon nanotubes paste electrode. Microchem. J., v. 85, p. 244, 2007.
YANG, S.F.; YANG, W. E.; KUO, W.H.; CHANG, H. R.; CHU, S.C.; HSIEH, Y. S. Antimetastatic potentials of flavones on oral cancer cell via an inhibition of matrix-degrading proteases. Archives of oral biology, v. 53, n. 3, p. 287-294, 2008.
YU, S.H.; ZHAO, G. C. Preparation of PlatinumNanoparticles-GrapheneModified Electrode and Selective Determination of Rutin. Int. J. Electrochem., p. 1, 2012.
YUAN, J?M. Green tea and prevention of esophageal and lung cancers. Molecular nutrition & food research, v. 55, n. 6, p. 886-904, 2011.
ZENG, L. M.; WANG, C. J., SU; J. Y., LI, D.; OWEN, N. L.; LU, Y.; LU, N.; ZHENG, Q. T. Flavonoids from the red alga Acanthophora spicifera. Chinese Journal of Chemistry, v. 19, n. 11, p. 1097-1100, 2001.
ZHANG, L. L.; LI, L.; WU, D-P.; FAN, J. H.; LI, X.; WU, K. J.; WANG X. Y.; HE, D-L. A novel anti?cancer effect of genistein: reversal of epithelial mesenchymal transition in prostate cancer cells1. Acta Pharmacologica Sinica, v. 29, n. 9, p. 1060-1068, 2008.
ZHANG, Y. Y.; LI, Z. C.; ZHU, J. K.; YANG, Z. Y.; WANG, Q. J.; HE, P. G.; FANG, Y. Z. Simultaneous determination of flavonoids and anthraquinones in chrysanthemum by capillary electrophoresis with amperometry detection. Chinese Chemical Letters, v. 21, n. 10, p. 1231–1234, 2010.
ZHANG, Y.; LIU, D. Flavonol kaempferol improves chronic hyperglycemia-impaired pancreatic beta-cell viability and insulin secretory function. European journal of pharmacology, v. 670, n. 1, p. 325-332, 2011.
ZHENG, L.; ZHANG, J. Q.; SONG, J. F. Ni(II)–quercetin complex modified multiwall carbon nanotube ionic liquid paste electrode and its electrocatalytic activity toward the oxidation of glucose. Electrochim. Acta, v. 54, p. 4559–4565, 2009.
ZHENG, W. F.; TAN, R. X.; YANG, L.; LIU, Z. L. Two flavones from Artemisia giraldii and their antimicrobial activity. Planta medica, v. 62, n. 2, p. 160-162, 1996.
ZHOU, J. R; GUGGER, E. T; TANAKA, T.; GUO, Y; BLACKBURN, G. L. CLINTON, S. K. Soybean phytochemicals inhibit the growth of transplantable human prostate carcinoma and tumor angiogenesis in mice. The Journal of nutrition, v. 129, n. 9, p. 1628-1635, 1999.
ZUAS, O.; HAMIMA, N.; SAMPORA, Y. Bio-synthesis of silver nanoparticles using water extract of Myrmecodia pendan (Sarang Semut plant). Materials Letters, v. 123, p. 156–159, 2014.
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